Antibacterial Activity of Zinc Oxide Nanoparticles against Some Multidrug-Resistant Strains of Escherichia coli and Staphylococcus aureus isolated from milk and milk products

Document Type : Original Article

Authors

1 bacteriology, mycology and immunology department faculty of vetrinary medicin menofia university

2 Bactriology,mycologyand immunology department faculty of vetrinary medicin menofia university

3 Department of Anatomy and Embryology Faculty of veterinary Medicine, Menoufia University

4 bacteriology immunology and mycology department faculty of vetrinary medicin benha university

5 Asst. Lecturer , of milk Hygiene and Control Department Faculty of Veterinary Medicine shebien Elkome– EL Monofia University

Abstract

Out of 100 milk samples (50 milk and 50 milk products) ,76% of milk samples from cattle and 68% from buffaloes tested positive for S. aureus, while 36% of yoghurt and 46% of cheese samples contained the bacterium. E-coli was detected in milk samples from cows and buffaloes, with proportions of 44% and 24% respectively, as well as in yogurt (24%) and cheese (36%).
The findings from the in vitro sensitivity test revealed that 57.6% of the 59 S. aureus isolates demonstrated high resistance to Trimethoprim \ sulphamethoxazole, whereas 71.7% exhibited high sensitivity to Clindamycin. Additionally, out of the 32 E.coli isolates, 71.8% demonstrated resistance to Ampicillin/Sulbactam, and 65.6% showed sensitivity to Clindamycin.
The ZnO nanoparticles showed MIC results of 2.5 µg/mL for E. coli and 1.25 µg/mL for S. aureus when they were separated. The MBC exhibited a concentration of 2.5 µg/mL against both E. coli and S. aureus. Scientists found that ZnO nanoparticles can be used instead of conventional antibiotics to treat subclinical mastitis in cows caused by E. coli and S. aureus infections, as well as to address the difficulties presented by bacteria that are resistant to multiple drugs

Keywords

Menoufia Veterinary Medical Journal
Volume 1, Issue 1 - Serial Number 1
المجلد الاول العدد الاول يونيو 2025
August 2025
Pages 1-16

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